Wednesday, October 31, 2012

Red Cross Raises $11-Million in Sandy Relief Efforts - Prospecting ...

A Red Cross volunteer comforts the resident of a damaged house in Toms River, N.J. (Les Stone/American Red Cross)

The American Red Cross announced that it has received more than $11-million in donations for its efforts to help the millions of families displaced by Superstorm Sandy.

Among the gifts announced today by donors to the Red Cross National Disaster Fund:

? The New York Yankees have given $500,000 to the charity to support relief efforts in New York, New Jersey, and Connecticut.

??Citi Foundation has given $100,000, on top of the $50,000 it gives annually to the disaster fund.

? CVS Caremark, the pharmacy chain, has given $50,000 in cash from its CVS Caremark Charitable Trust and another $50,000 in food and bottled water, which will be distributed to storm victims in New Jersey.

? United Airlines Foundation has announced it will provide up to $50,000 to match donations made to the Red Cross, Feeding America, or AmeriCares on the Crowdrise fundraising platform. It will also give members of its frequent-flier program bonus miles for contributing to those charities.

Emma Carew Grovum contributed to this report.

Send an e-mail to Raymund Flandez.

Source: http://philanthropy.com/blogs/prospecting/red-cross-raises-11-million-in-sandy-relief-efforts/36038

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Netflix shares soar after Icahn reports 10 percent stake

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Super PACs, nonprofits favored Romney

By Michael Beckel and Russ ChomaCenter The Center for Public Integrity/The Center for Responsive Politics

Super PACs and nonprofits unleashed by the Citizens United Supreme Court decision have spent more than $840 million on the 2012 election, with the overwhelming majority favoring Republicans, particularly GOP presidential nominee Mitt Romney.

Who are the Mega Donors giving millions to pro-Obama and pro-Romney Super PACS to help pay for negative ads in the closing days of the campaign? NBC's National Investigative Correspondent Michael Isikoff reports on big donors with some specific agendas.?

An estimated $577 million, or roughly 69 percent, was spent by conservative groups, compared with $237 million spent by liberal groups, or about 28 percent, with the remainder expended by other organizations.

Of all outside spending in the 2012 election, more than $450 million was dedicated to the presidential election with more than $350 million spent helping Romney and about $100 million spent to help President Barack Obama.

The spending helped close the gap on Obama?s considerable fundraising advantage over Romney. As Election Day approaches, Romney and Obama are neck-and-neck in national polls.


The totals are from a joint analysis of Federal Election Commission data by the Center for Responsive Politics and the Center for Public Integrity. The analysis covers the period from Jan. 1, 2011, through Oct. 28, 2012, and does not include independent spending by the political party committees.

The final tally will be higher as spending continues to accelerate before Election Day.

Obama's campaign raised more than $632 million in the 2012 election, 62 percent more than Romney's $389 million. Even when including money raised by the Democratic and Republican National Committees, Obama still has an edge of more than $166 million: $924 million for the president?s re-election team vs. $758 million for Romney and the GOP.

The president?s campaign committee was bankrolled to a great degree by money from grassroots supporters, while Romney relied more heavily on larger donors. Individuals who gave $200 or less accounted for 34 percent of Obama?s war chest. Meanwhile, such small-dollar donors were responsible for only 18 percent of the Romney campaign?s haul.

The deluge of outside spending was made possible by the 2010 Citizens United decision and a lower court ruling that allowed individuals, labor unions and corporations to give money to outside spending groups ? mostly nonprofits and super PACs ? to buy advertising attacking or supporting candidates.

Super PACs were generally backed by super donors. Billionaire casino magnate Sheldon Adelson and his family, for example, gave $54 million to Republican super PACs as of mid-October, far more than any other donor this election cycle.

Nonprofit ?social welfare? groups and trade associations can raise just as much money, but are not required to report their donors. The lack of transparency sparked legislation to require disclosure, but it was defeated.

Nonprofits were responsible for more than $245 million, or about 30 percent, of the $840 million in total outside spending. That?s about $100 million more than they spent in 2010.

Spending surge helps Romney
During the week of Sept. 30, about $16.5 million was spent by outside groups benefiting Romney, mostly on ads attacking Obama. Three weeks later, the seven-day total jumped to more than $55 million, according to FEC filings.

Outside spending benefiting Obama over the same period never exceeded $14 million, records show.

The GOP candidate, facing the Obama fundraising juggernaut, needed the help of outside groups to keep pace.

The Obama campaign aired nearly three times as many ads as the Romney campaign between late April and late October, according to a recent study by the Wesleyan Media Project.

Wesleyan found that the 460,500 ads aired by the Obama campaign in the presidential election was more than the Romney campaign, the RNC and seven other Republican-aligned outside spending groups combined ? including the top GOP super PACs Restore Our Future and American Crossroads and conservative nonprofits Crossroads GPS and Americans for Prosperity.

Super PACs in the 2012 election raised about $660 million.

Restore Our Future alone accounted for about $1 out of every $5 of all super PAC donations received. The pro-Romney group raised more than $130 million, much of which was spent decimating Romney?s rivals during the GOP primaries.

The Obama-backing Priorities USA Action, by contrast, raised $64 million.

In 2010, during their first year of existence, all super PACs combined raised just $85 million.

The top 149 individual super PAC donors ? each of whom has contributed at least $500,000 ? are responsible for $290 million of funds raised.

And 858 individuals who contributed at least $50,000 to super PACs accounted for nearly 60 percent of all money the groups collected in the 2012 election. The median household income in 2011, by way of comparison, was $50,054, according to the U.S. Census Bureau.

Donations from large, publicly traded corporations have been relatively rare, but in the waning weeks of the campaign, oil and gas giant Chevron wrote a $2.5 million check to the Congressional Leadership Fund, a super PAC backing Republican candidates that is closely associated with House Speaker John Boehner, R-Ohio.

The emergence of super PACs has been heralded by some, such as Republican lawyer Brad Smith, the former chairman of the Federal Election Commission who co-founded the conservative Center for Competitive Politics.

?(Super PACs) have helped to level the playing field between Romney and Obama, whereas otherwise Obama?s spending advantage would have been substantial,? said Smith. ?And in some cases they have raised issues that concern voters that the candidates have chosen to avoid.?

Others disagree.

?When elected officials rely on the most-wealthy of wealthy Americans, it means the voices of everyday people lose out,? said Nick Nyhart, president of the advocacy group Public Campaign, which favors publicly financed elections.

Unlike traditional political action committees, super PACs have no contribution limits and the funds they raise can't be directly donated to candidates. Instead, the money they raise has primarily been used to fund attack ads.

Prior to Citizens United, groups that wanted to expressly advocate for or against a candidate were limited to receiving no more than $5,000 per donor per calendar year.

Donations shrouded in secrecy
As important as super PACs were in the 2012 election, the loosening of political spending rules for non-disclosing, nonprofit organizations was also a key development following the Citizens United decision.

GOP-aligned nonprofits have outspent their Democratic counterparts by a ratio of more than 8 to 1.

Notably, this figure represents a conservative tally of nonprofits? political spending.

Federal law requires spending to be reported only if a group's advertisements encourage viewers to vote for or against a candidate, or if they mention a candidate shortly before a political convention or election.

Justice Anthony Kennedy, the author of the Court's Citizens United 5-4 opinion, made a point of saying that disclosure was a key part of the court?s rationale. Disclosure would allow citizens to monitor the new political activity.

"This transparency enables the electorate to make informed decisions and give proper weight to different speakers and messages," he wrote.

But the tax-exempt groups ? some of which clearly exist for no other reason than to elect favored candidates ? are spared by Internal Revenue Service and FEC rules from having to publicly reveal their donors.

Crossroads GPS, co-founded by GOP strategist Karl Rove, claims in press releases to have spent more than $120 million since January 2011, of which only $57 million has been reported to the FEC. At least $12 million has been spent attacking Obama, according to FEC records.

Voters watching its ads have no idea where the money is coming from. Nor do they know who is funding the work of liberal organizations doing the same thing, albeit with a lot less money.

Patriot Majority has reported spending $6.5 million on ads, more than half of which has opposed Rep. Dean Heller, the Republican who is running for U.S. Senate in Nevada.

Not all secret money is coming from nonprofits. Throughout the election season, mystery corporations have popped up, spending huge sums.

Specialty Group Inc. of Knoxville, Tenn., wrote seven checks totaling $5.2 million to pro-Tea Party super PAC FreedomWorks for America in early October. The corporation was created on Sept. 26. The name and address listed on incorporation records are those of a Knoxville, Tenn., area attorney. His published phone line has been disconnected.

The source of the funds, as of this writing, is unknown.

Meanwhile, more than $10 million in funds given to super PACs, which disclose donors regularly, have come from nonprofits, showing that even the groups required to be transparent about their funding sources can still shield the names of donors.

Going negative

The explosion in outside spending has coarsened the political debate, flooding the airwaves in Ohio, Florida, Virginia and other battleground states with negative, often inaccurate ads.

Roughly 80 percent of all spending by both conservative groups and liberal groups has been negative, FEC records indicate.

Fully 100 percent of the nearly $57 million Priorities USA Action reported spending has been on negative ads.

The group, which coined the slogan ?If Mitt Romney wins, the middle class loses,? linked Romney to the death of a woman who lost her battle with cancer.

Another of the super PAC?s most memorable ads featured a worker describing how building the stage on which officials announced the plant?s closure, after it was bought by Bain Capital, was like building his ?own coffin? and made him ?sick.?

Eighty-eight percent of Restore Our Future's spending went toward negative ads, as did 95 percent of American Crossroads' expenditures.

Many of these ads have criticized Obama?s handling of the economy, arguing that the country ?can?t afford? four more years of Obama?s policies. One spot features a small-business owner saying, ?We can?t create more jobs until Obama loses his.?

Others ads have featured disillusioned Obama supporters from 2008 expressing disappointment with the president.

The winners in the post-Citizens United campaign finance regime won?t be known for certain until after Election Day. But Ciara Torres-Spelliscy, an assistant professor of law at Stetson University's law school who previously worked as an attorney with the Brennan Center for Justice, said it won?t be the voters.

?I fear that we have lost elections on a human scale with post-Citizens United spending by super PACs? and non-disclosing groups, she said. ?The losers here are voters who get carpet bombed with political ads full of half-truths and distortions.?

Researchers Robert Maguire of the Center for Responsive Politics and Alexandra Duszak of the Center for Public Integrity contributed to this report.?

This story is a collaboration between the Center for Public Integrity and the Center for Responsive Politics. For up-to-date news on outside spending in the 2012 election, follow our Source2012 Tumblr and the hashtag #Source2012 on Twitter.

More from Open Channel:

?

  • N.C. neighbors aghast to learn drinking water contaminated for years
  • In Mali, land of 'gangster jihadists,' ransoms help fuel the movement
  • Plane truth: Millions spent on rarely used Gary, Ind., airport
  • Feds investigate phony letters telling Fla. voters they're not eligible to vote
  • 'Cash register justice'; private probation services face legal counterattack
  • Sunni radicals target Shiites to fan sectarian flames in Pakistan
  • Unstoppable hackers take out bank websites with next-gen 'botnets'
  • Ex-CIA agent pleads guilty to leaking identity of covert operative
  • 'Hurricane tort king' wires another $1 million to pro-Obama Super PAC
  • ?

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    Source: http://openchannel.nbcnews.com/_news/2012/10/30/14810571-pro-romney-super-pac-spending-narrows-obama-fundraising-advantage?lite

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    Boeing to sell 35 new 737 airplanes to Russia

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    Yelp's new picture-heavy menus give you a better look at that Baby Back Rib Tickler

    Yelp's new pictureheavy menus give you a better look at that Baby Back Rib Tickler

    Needless to say, we're all well aware of Yelp's popularity amongst people who love a thing or two about visiting restaurants and, in turn, eating some good ol' food. And while the service could be considered relatively great as is, it never hurts to see a few new features added here and there -- especially one as useful as the new "Explore the Menu," which is made possible by everyday users like yourself. The newfangled menu system will allow folks to upload pictures of any grub item they've tried at frequented restaurants, making it easier for future goers to have a slight idea of what to expect should they be interested in trying a particular dish from one of the many places listed within Yelp. The novel menu pages will be rolling out to business pages today in the US, with Yelp noting that this will be the "first time ever" it's simultaneously launching a fresh service across its OG site, mobile website and applications.

    Filed under: ,

    Yelp's new picture-heavy menus give you a better look at that Baby Back Rib Tickler originally appeared on Engadget on Tue, 30 Oct 2012 23:33:00 EDT. Please see our terms for use of feeds.

    Permalink TechCrunch  |  sourceYelp  | Email this | Comments

    Source: http://www.engadget.com/2012/10/30/yelp-new-explore-the-menu-feature/

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    Android 4.2 gallery and camera ported to Galaxy Nexus

    Android 4.2 camera  Android 4.2 camera

    That awesome camera app, as well as the new Gallery we saw from the upcoming Android 4.2 release  can now be installed on your Galaxy Nexus running Android 4.1.1.

    There's still a bug in the photosphere portion, but dmmarck, the fellow working in it, says he has some ideas and will continue to look at things for a fix.

    Be sure to visit the forum thread for the full instructions, as this one needs a bit of hackery to install. 

    Source: Android Central forums



    Source: http://feedproxy.google.com/~r/androidcentral/~3/j4sowsB9S8M/story01.htm

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    Tuesday, October 30, 2012

    Celebrating Autumn All Year Round ... By Becoming A Leaf

    It is autumn, and where I live the leaves are peaking; there is a riot of them everywhere, narrow ones, broad ones, droopy ones, crunchy ones. Leaves come in so many shapes, hues, textures ? the closer you look, the more differences you see. Botanists have names for every leaf type, and clumped together, says writer Robert Dunn, they sound like free verse poetry ...

    pinnate, ciliate, barbellate, bearded, canescent, glabrous, glandular, viscid, scurfy, floccose, arachnoid, and my favorite, tomentose (covered with woolly hairs).

    But to us, they're just leaves, and this week they're just winding up their show, taking a last shot at the sunshine before they catch a breeze and waft away. This is their brief time to be admired.

    Which we do. And then we go on to other things. That's why I'd like to introduce you to a better class of leaf admirer.

    The creatures I'm talking about don't drive to a Vermont hotel for one weekend a year. No, they spend every day of their lives not just liking leaves, but pretending to be leaves, which I think is a much higher form of praise.

    Check out these leaf mimic katydids. They're not content to just look like a plain green leaf. "That would be too easy," says entomologist and wildlife photographer Piotr Nasrecki

    "No, their bodies are perfect replicas of leaves that have been chewed up, torn, rotten, dried up, partially decayed, or covered by fungi. Some even have fake holes in their wings (fake, because the holes are in fact thin, translucent parts of the wing membrane.)"

    This next one, a Costa Rican Leaf katydid, goes a step further. It looks like a leaf that's been eaten, or has what's called a "necrotic" or diseased edge. A monkey looking around for a juicy katydid to munch on would have a hard time seeing this as anything but a leaf.

    This isn't, by the way, a standard act of mime. You won't find thousands of katydids with the exact same bite-on-the-edge look. "No two individuals are alike," says Piotr Nasrecki. In fact, "you can find individuals whose appearance is so dramatically different that one would feel justified to place them in different species." But they're not. These are, you should excuse the expression, artists: individuals pretending, in their very different ways, to be a leaf.

    The biological explanation is that the tamarind monkeys who want to eat them are excellent hunters. They comb through foliage, unfurl leaves, and look closely for insects hiding in plain sight. If katydids had 10 standard imitations, the monkeys would learn those types and spot them every time, but says Piotr, "when every individual in the katydid population looks slightly different, then the task of finding them is much more difficult."

    And now comes my finish: This is the most beautiful deceit of all ? and it's seasonally appropriate!

    This here is a leaf katydid from Guyana. See if you can find it.

    These insects don't have hidden colors under their wings that they can flash to frighten predators. They're just boringly brown. So when a predator approaches, they do what October leaves do where I live. They float gently to the ground and play dead.

    Meryl Streep would be jealous.


    You can learn about these katydids in more detail on Piotr Nasrecki's blog, called "The Smaller Majority". He takes the photos, he tells the stories, he knows the science. He also posts all the time, so if you are hungry for bug stories of every sort, check him out. He also has a new book, just published, called Relics.

    But if your passion is leafy, not buggy, then may I suggest yet another great leaf appreciator. This one doesn't just gaze at leaves, or pretend to be one; instead, he scissors them into startlingly funny shapes, taking leaves to places they've never been before. His name is Christoph Niemann, and if you haven't seen his leaves, you haven't experienced the full possibilities of autumn.

    CLICK HERE TO SEE LEAVES BEHAVING ODDLY

    Source: http://www.npr.org/blogs/krulwich/2012/10/29/163704088/celebrating-autumn-all-year-round-by-becoming-a-leaf?ft=1&f=1007

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    Researchers engineer cartilage from pluripotent stem cells

    ScienceDaily (Oct. 29, 2012) ? A team of Duke Medicine researchers has engineered cartilage from induced pluripotent stem cells that were successfully grown and sorted for use in tissue repair and studies into cartilage injury and osteoarthritis. The finding is reported online Oct. 29, 2012, in the journal the Proceedings of the National Academy of Sciences, and suggests that induced pluripotent stem cells, or iPSCs, may be a viable source of patient-specific articular cartilage tissue.

    "This technique of creating induced pluripotent stem cells -- an achievement honored with this year's Nobel Prize in medicine for Shimya Yamanaka of Kyoto University -- is a way to take adult stem cells and convert them so they have the properties of embryonic stem cells," said Farshid Guilak, PhD, Laszlo Ormandy Professor of Orthopaedic Surgery at Duke and senior author of the study.

    "Adult stems cells are limited in what they can do, and embryonic stem cells have ethical issues," Guilak said. "What this research shows in a mouse model is the ability to create an unlimited supply of stem cells that can turn into any type of tissue -- in this case cartilage, which has no ability to regenerate by itself."

    Articular cartilage is the shock absorber tissue in joints that makes it possible to walk, climb stairs, jump and perform daily activities without pain. But ordinary wear-and-tear or an injury can diminish its effectiveness and progress to osteoarthritis. Because articular cartilage has a poor capacity for repair, damage and osteoarthritis are leading causes of impairment in older people and often requires joint replacement.

    In their study, the Duke researchers, led by Brian O. Diekman, PhD, a post-doctoral associate in orthopaedic surgery, aimed to apply recent technologies that have made iPSCs a promising alternative to other tissue engineering techniques, which use adult stem cells derived from the bone marrow or fat tissue.

    One challenge the researchers sought to overcome was developing a uniformly differentiated population of chondrocytes, cells that produce collagen and maintain cartilage, while culling other types of cells that the powerful iPSCs could form.

    To achieve that, the researchers induced chondrocyte differentiation in iPSCs derived from adult mouse fibroblasts by treating cultures with a growth medium. They also tailored the cells to express green fluorescent protein only when the cells successfully became chondrocytes. As the iPSCs differentiated, the chondrocyte cells that glowed with the green fluorescent protein were easily identified and sorted from the undesired cells.

    The tailored cells also produced greater amounts of cartilage components, including collagen, and showed the characteristic stiffness of native cartilage, suggesting they would work well repairing cartilage defects in the body.

    "This was a multi-step approach, with the initial differentiation, then sorting, and then proceeding to make the tissue," Diekman said. "What this shows is that iPSCs can be used to make high quality cartilage, either for replacement tissue or as a way to study disease and potential treatments."

    Diekman and Guilak said the next phase of the research will be to use human iPSCs to test the cartilage-growing technique.

    "The advantage of this technique is that we can grow a continuous supply of cartilage in a dish," Guilak said. "In addition to cell-based therapies, iPSC technology can also provide patient-specific cell and tissue models that could be used to screen for drugs to treat osteoarthritis, which right now does not have a cure or an effective therapy to inhibit cartilage loss."

    In addition to Guilak and Diekman, study authors include Nicolas Christoforou; Vincent P. Willard; Alex Sun; Johannah Sanchez-Adams; and Kam W. Leong.

    The National Institutes of Health (AR50245, AR48852, AG15768, AR48182, Training Grant T32AI007217) and the Arthritis Foundation funded the study.

    Share this story on Facebook, Twitter, and Google:

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    Story Source:

    The above story is reprinted from materials provided by Duke University Medical Center.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/nTX8lG32Zao/121029154322.htm

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    33 Feet Christmas Holiday Lights String with 100 LED warm white ...

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    Source: http://hobrosolutions.com/33-feet-christmas-holiday-lights-string-with-100-led-warm-whiteby-ledwholesalers-2021ww/

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    Puerto Rico: Statehood bid complicated by a struggling economy ...

    SAN JUAN, Puerto Rico ? This November Puerto Ricans could vote to ask the United States to make the territory a state. If they do the U.S. Congress will have much to consider about the island?s economic situation and how it could affect the rest of the country.

    Puerto Rico?s economy has experienced a downward spiral since the 1970s. Based on tax-incentivized investments from big business and the largesse of big government, the current economic model isn?t working, according to key officials and opinion-makers interviewed by the Cronkite Borderlands Initiative.

    Puerto Rico?s unemployment rate is almost double the U.S. mainland?s rate. The labor force participation rate is one of the lowest in the world, an indication that a high percentage of Puerto Ricans find it better to depend on government benefits than to work.

    Puerto Rico?s per capita income of $15,203 is not even half that of Mississippi, the poorest state in the U.S. The island?s largest employer is the government. U.S.-based businesses reap tax benefits as foreign investors, but their profits haven?t been invested locally to fuel the infrastructure, growth and job development that were envisioned.

    ?We do have the poverty we have, and we need to deal with [it], and that?s an issue,? said Puerto Rico?s Resident Commissioner Pedro Pierluisi, who represents Puerto Rico in a non-voting capacity in Congress. ?That?s going to be an issue as a state, as a territory, regardless.?

    The Economist magazine calculated that from 1990 to 2009, the U.S. government spent $182 billion more in Puerto Rico than it received from the territory in taxes. Eleven other states had a higher deficit, but Puerto Rico?s deficit was the highest when evaluated as a percentage of its annual economic output, Gross Domestic Product.

    Puerto Rico?s deficit was 290 percent of GDP. Comparable measurements indicated that the closest states were New Mexico, Mississippi and West Virginia. The conclusion? Puerto Rico benefits more from federal expenditures than any of the poorest U.S. states.

    But for Puerto Ricans, the issues are much deeper than simple economic ones. They are rooted in a paradoxical relationship with the U.S. that many Puerto Ricans view as both paternalistic and second class.

    As United States citizens, Puerto Ricans can travel freely to and from the mainland and serve in the U.S. military. But Puerto Ricans cannot vote in general presidential elections. They have one non-voting delegate in the U.S. Congress, Pedro Pierluisi, who holds the title ?resident commissioner.?

    Statehood supporters cut across the political spectrum. Pierluisi and Gov. Luis Fortu?o are both members of the pro-statehood New Progressive Party. Pierluisi is a member of the U.S. Democratic Party, while Fortu?o serves on the Republican National Committee. They view statehood as the means to building the island?s future.

    ?The crux of the matter is the lack of political rights. That?s not right in the 21st century,? said Pierluisi. ?The model has worked in 50 states, why shouldn?t it work here??

    But Puerto Rico, for many reasons, would be unique among U.S. states, and its economy would be the weakest.

    The Deterioration of Puerto Rico?s Economy

    So where did Puerto Rico?s economy go wrong? An outdated economic model may be to blame. While it may have worked at one time, proponents of statehood say it no longer makes sense.

    Code section 936 of the U.S. Internal Revenue Code, also known as the Possessions Tax Credit, granted tax-free income to U.S. corporations in Puerto Rico to promote economic growth. This credit was repealed by the Small Business Act beginning in 1996, but that measure set up a 10-year transition that allowed U.S. corporations to claim 60 percent of wages and capital investments as allowances against corporate income taxes.

    Former Gov. Carlos Romero Barcel? said that ?initially it was a good gimmick to attract industries to come to Puerto Rico.? However, Romero felt that tax credits based on payroll would have done more to provide jobs to Puerto Ricans. Romero said he has recently suggested to President Barack Obama that such a policy would attract those industries that are considering foreign investment in China and other emerging economies.

    In 2002, U.S. based businesses were the source of 71 percent of the manufacturing sector?s ?value added? in Puerto Rico, according to a 2006 U.S. Government Accountability Office study.

    ?Value added? is the total value of what a business produces minus overhead costs. But experts say the majority of profit from this high level of production returns to the U.S. mainland, instead of shoring up the economy in Puerto Rico.

    Even after the expiration of section 936, U.S. corporations have remained because of the island?s established labor force and infrastructure. Further, financial burdens are still eased with favorable tax laws ? the maximum tax rate for foreign companies operating out of Puerto Rico is 7 percent.

    According to economist and University of Puerto Rico-Rio Piedras professor, Carlos Col?n de Armas, many commonwealth defenders wrongfully attribute the end of the tax incentives of section 936 to the economic problems of the island.

    ?The truth of the matter is that the deterioration of the economy began in the 70s and 936 was enacted in the 70s,? said Col?n de Armas. ?Because we thought that everything was going to be solved because of 936, we didn?t adapt to globalization, we didn?t adapt to the current world trends.?

    The tax subsidy hasn?t been beneficial for the U.S. treasury, either. It?s estimated that tax credits for U.S. firms in Puerto Rico cost the U.S. approximately $3 billion yearly, according to the 2006 GAO study.

    The inefficiencies of the tax system do not end there said former Sen. Miriam Ram?rez de Ferrer, who has been a long-time fighter of subsidized tax policies.

    ?We have a false economy. We?re a foreign country for ushered tax benefits for multi-national corporations,? said Ram?rez. ?But we are a territory with U.S. citizens. What are we??

    ?Foreign? or not, one of the reasons Puerto Rico sought outside capital was to gain more political freedom. However, the corporations established through section 936 controlled economic development strategies of the Popular Democratic Party and tried to control those of the New Progressive Party, said Carlos Chard?n, Puerto Rico?s assistant secretary of state for government affairs.

    ?[Puerto Rico] ended up being captive of the party. You cannot separate capital and finance and all that from politics,? said Chard?n. ?We can separate it for the purpose of a study, but essentially it?s one in the same thing.?

    With so much emphasis on foreign capital over the years, Puerto Rico?s domestic economy hasn?t prospered. Its Gross National Product (GNP), a measure of how the residents of a country are doing economically, has dropped dramatically in the past 40 years. In 1970, the GNP was 93 percent of Gross Domestic Product (GDP), a measure of the strength of a country?s domestic economy. This meant that almost all of the products and services produced in Puerto Rico came from domestic sources. Forty years later, in 2010, local production comprised only 65.8 percent of total production.

    ?Puerto Ricans shot themselves in the foot with the economic development program they designed,? said Chard?n. ?They did not use the capital that existed locally to develop.?

    Increasingly Dependent on the U.S. Government

    In addition to its reliance on outside investment, Puerto Rico has become increasingly dependent on Washington. Of the approximately $22 billion it receives from the U.S. annually, more than $6 billion went towards federal aid such as food stamps and funding for low income housing in 2011.

    Rather than empowering Puerto Ricans and encouraging a strong manufacturing and small-business platform, the system encourages government handouts, said Franklin Delano L?pez, former chairman of the New Democratic Party of Puerto Rico.

    ?The failure that we?re seeing on the island in terms of economy, in terms of violence and corruption,? said L?pez, ?is a result of a failed educational system that has been designed within the framework of a paternalistic society.?

    Welfare incentives mean families are often better off accepting federal assistance than they would be working low-wage jobs, explained Ricardo ?Ricky? Rossell? Nevares, son of former Gov. Pedro Rossell?, who led Puerto Rico from 1993-2001. Taking a job may mean losing benefits for your children, your house and other economic incentives.

    ?The system itself is designed to keep you dependent, to keep you away from those opportunities,? said Rossell?, ?and I think that the only way to change it is if we get the power to choose what the future of Puerto Rico is.?

    Aguadilla Mayor Carlos M?ndez said that more emphasis is needed on improving the educational system to give Puerto Ricans the tools to make better, smarter decisions.

    ?I don?t believe in welfare,? said M?ndez. ?I don?t want the United States to give me a fish; I want them to teach me how to fish, so I can make my own living.?

    These dire economic situations, said Ram?rez de Ferrer, the former senator, have put the island in a low mood, which in turn has fostered a burgeoning drug trade and increasing violent crime. In 2011, 1,136 people were murdered on the island, marking its deadliest year in history. That?s an average of three violent deaths per day and a per capita murder rate about twice that of Mexico.

    ?OK. So you don?t want statehood for Puerto Rico? We?re just going to move into your backyard and see how you feel about it,? said Ram?rez de Ferrer. ?That?s what?s happening.?

    Puerto Ricans are increasingly moving stateside. As the second largest Latino population group in the United States, there were over 4.6 million Puerto Ricans living in the United States in 2010, according to the U.S. Census Bureau. This tops the number of Puerto Ricans living in Puerto Rico, which was approximately 3.7 million in 2010.

    Migration throughout the nation and in and out of Puerto Rico is normal, said former San Juan Mayor Hern?n Padilla. It?s the ?why? that?s become worrisome. Padilla said too much of the migration is fueled by fear.

    ?The fear of not having a good job, the fear of poor quality of life, the fear of crime rate because of drug trafficking,? said Padilla. ?If the decision is to move because, ?I want to improve and I can,? go for it.?

    Better financial opportunities, said Luis D?vila Col?n, commentator and political analyst, is the reason behind Puerto Rico?s so-called ?brain drain.? Doctors, lawyers, and other professionals have little incentive to remain on the island if they can earn three times as much on the mainland United States.

    For those not moving out, many appear to be giving up. The labor force participation rate in Puerto Rico is one of the lowest in the world, with about four out of 10 people employed or seeking employment. Puerto Rico had an unemployment rate of 13.5 percent in August 2012, down from 15.5 percent a year ago August, reported the Bureau of Labor Statistics. The U.S. unemployment rate in August was 8.1 percent.

    In October 2009 when nearly a quarter of the workforce was employed by the public sector, Gov. Luis Fortu?o unveiled plans to slash thousands of government jobs. With Law 7, about 13,000 government workers were laid off and an additional 4,000 left the central government voluntarily, taking advantage of early retirement incentives. The massive layoffs were met with weeks of protests by union workers and student protests at universities, creating an unpopular sentiment among Puerto Ricans. Employment has shrunk by thousands more since then as municipal governments and public corporations continue cutting jobs.

    Still, the huge government presence subsists. According to the Bureau of Labor Statistics, there were approximately 266,400 government jobs in Puerto Rico in August 2012.

    D?vila Col?n contends that the vast majority of those jobs aren?t needed. In fact, he claims the island could get by with only 75,000 of those jobs.

    ?When you see somebody from the electric company there, you see the guy pulling the bulb and three guys looking and having coffee. Why?? he asked. ?The public payroll has been used as an easy way for job creation.?

    Chard?n, the assistant secretary of state, agrees. The invention of jobs in the government sector hurts the private sector, he said, and the system for starting a business is already complex.

    ?You can?t run a business when you?ve got one-fourth of people working in government looking after you,? said Chard?n. ?Not really looking after you, running after you!?

    The Fight for Statehood

    Padilla said ?el s?ndrome del mango bajito,? a phrase that means Puerto Ricans are always picking the lowest-hanging fruit, is the root behind support for the status quo. He also said that lately, this concept has been increasingly challenged.

    What Padilla describes can be explained by behavioral economics or the natural inclination to take the easy route, said Col?n de Armas. People make decisions on the wrong basis and consequently, the economy of Puerto Rico is often analyzed in the wrong way, he said.

    ?We give more importance to inputs over outputs. If you think about it, the factors sound like they are better under the current status,? Col?n de Armas said. ?We are able to give tax incentives ? ?oh that?s good? ? but what about the results??

    Would the average Puerto Rican be better off under statehood? That question has spawned endless debate. Many see it as a question of tax burden versus benefits.

    Contrary to widespread misconception, Puerto Ricans do pay U.S. federal taxes for Social Security and Medicare. They also pay federal taxes on sources of income outside the island, such as capital gains on stock transactions.

    Unless Puerto Ricans are employed by or do business with the federal government, they do not pay U.S. federal income taxes. However, Puerto Ricans have their own income tax system, which is modeled after the U.S. tax system. In addition to their Commonwealth tax burden, residents of Puerto Rico collectively paid more U.S. federal income taxes in 2010 than residents of Vermont, according to the IRS.

    It?s the working and middle classes in Puerto Rico who bear the brunt of the tax burden says D?vila Col?n, the island?s most well-known political analyst and commentator. And they?re afraid of losing current benefits.

    ?It?s like a Catch 22,? said D?vila Col?n. ?The ones at the top don?t want to pay federal taxes. The ones at the bottom feel that any change may alter their cradle-to-grave welfare system.?

    But resistance to statehood is driven by more than economic considerations. The fear of losing Puerto Rico?s cultural identity concerns many, but former Gov. Romero argues this is nonsense.

    ?Is that going to change the way we think? Are we going to stop going to the church that we go to? Are we going to stop thinking about our parents the way we think about them?? said Romero. ?The only way that a culture changes is when an overwhelming number of people from outside with a stronger or just as strong culture come in.?

    Diversion to other, often petty issues by political parties, D?vila Col?n said, also takes away from what?s really important ? solutions for the economy. As a nation Puerto Rico must reorganize all its priorities, D?vila Col?n said.

    ?It?s more than economics. We?re in the middle of a democratic revolution. We?re in the middle of a major social change,? said D?vila Col?n. ?We just don?t see it. We don?t see it because we?re stuck on the little issues.?

    The island remains split on the issue of statehood. Getting past these barriers will require a well-liked, trusted leader ? something Puerto Rico currently lacks say proponents of statehood. Puerto Ricans are more partisan than in the states, said former San Juan Mayor Padilla, but of primary importance is strong leadership.

    ?If you?re in government, you must show that you are running a good government,? Padilla said. ?You must be an example of good administration. You must be a role model.?

    Some claim that Puerto Rico hasn?t had a real leader since Gov. Pedro Rossell?, who served as the sixth governor of Puerto Rico from 1993 to 2001.

    The former governor?s youngest son, Ricardo ?Ricky? Rossell?, just may have inherited his knack for leadership in politics. While he?s too young to run for governor at the age of 33, there?s much talk of him running for office in the future.

    Rossell? currently resides part time in the U.S. and works as a stem cell researcher at Duke University?s Howard Hughes Medical Institute; however, as a private citizen he does much more. For three years now, Rossello has traveled throughout the island with a grassroots initiative, encouraging a full campaign for statehood embodied by Puerto Ricans themselves.

    Past efforts, he contends, have proven unsuccessful; statehooders cannot expect a different result unless they enter into real conversation with the pro-commonwealth and independent parties.

    ?Creating a crisis is what drives issues,? Rossell? said. ?If we don?t do something now, in the near future, I think we may lose many of the benefits, or many of the nice things we have to say about Puerto Rico.?

    Rossell? is trying to introduce another message among Puerto Ricans. The issue of political status has been defined as one of parties, Rossell? said. Yet Puerto Ricans must look at the data more objectively because the colonial system affects not just one party, but everybody residing on the island.

    ?The worst bias in Puerto Rico is not necessarily color. It?s political,? said Rossell?. ?Our effort is to enable people who have historically been for a system just because they?re loyal to a party, to be able to detach it.?

    Despite these roadblocks, the process of assimilation to the United States has begun and statehooders are confident that with time, Puerto Rico will attain statehood.

    ?It?s humanity that binds us after all, and in the end, what makes nations is a common bond of economics, interests, values ? so it?s inevitable,? said D?vila Col?n. ?When it will come, I don?t know.?

    Source: http://cronkitenewsonline.com/2012/10/puerto-rico-statehood-bid-complicated-by-a-struggling-economy/

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    Monday, October 29, 2012

    Do You Want To Earn Money | Design Thinking Exchange

    If you are not earning enough money from a job and you want to make better life-work balance and need to spend more time with family and friends. These are some main reasons why many people are looking for opportunities to earn money online with help of internet. Having your own online business and earn money on the internet brings many benefits, aspiring online entrepreneurs fail because they do not know the essential things they must look for in a business opportunity nowadays generally.

    To make matters worse, today the internet (in French it is known as ?gagner de l?argent?) is full of scams or frauds which prey on those people wants to earn money on the internet. If you want to earn money on the internet, it is very important that you read and follow what is outlined this article. If the online business you are considering involves affiliate programs, you must make sure that the company has a good reputation and positive reviews only. The most important is the time during which the program has been operating. The longer the business opportunity program has been operating, the better because it shows that it?s a solid business. You also talk to other people who actually earn money on the internet using that same program that you are considering to join or recently joined.


    Source: http://www.designthinkingexchange.com/do-you-want-to-earn-money/

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    Insurers prepare for impact of Hurricane Sandy

    By Ben Berkowitz , Reuters

    Tom Mihalek / Reuters

    A crew works to board up a business Sunday in Ocean City, N.J., in preparation for Hurricane Sandy.

    BOSTON ??Insurers say they are making the usual preparations for a hurricane ? activating claims teams, staging adjusters near the locations most likely to be affected and generally getting ready to pay for a potentially huge volume of losses.

    "We plan for weather events such as this, so we feel well prepared with resources strategically positioned to quickly assist customers who may be impacted," Travelers spokesman Matthew Bordonaro said in an early Sunday e-mail.

    Hurricane Sandy takes aim at Eastern Seaboard

    Travelers is the third-largest insurer in New York for both personal home and auto and commercial lines of insurance, and the second-largest in Connecticut.

    Bordonaro said the company had also activated continuity plans for its own employees, so it can sustain operations despite having staff clustered in New York and Hartford.

    Had Sandy hit in 2011, it may have been more of a problem for the insurance industry, which dealt with record-breaking losses around the world last year, mostly from U.S. tornadoes and Asia-Pacific earthquakes.

    But in 2012, most insurers' disaster losses are down substantially, leaving them with more capacity to absorb the billions of dollars in costs some expect from Hurricane Sandy.

    "In terms of losses, I certainly don't think it's going to be the largest loss of the last 100 years," Tom Larsen, senior vice president of Eqecat, said in an interview late Friday. "It's not an end-of-days scenario."

    Hurricane Tracker: Follow storm's location

    Chubb Corp, another of the major insurers in the Northeast, said early Sunday that it has been working for days to move staff around so they are positioned to respond.

    Weather is unlikely to interfere with claims processing, a spokesman said, even though the company is headquartered in New Jersey, Chubb has a major center in Arizona that can handle claims as needed.

    State Farm, the country's largest home and auto insurer and the market leader in New York and New Jersey, said late Saturday it had agents and catastrophe teams on standby waiting for Sandy's arrival.

    "We'll be ready to handle claims as soon as the storm hits," a spokeswoman said.

    Allstate, which trails close behind State Farm in the home and auto market, said it was placing its catastrophe response teams in North Carolina, Pennsylvania and Virginia to be able to respond more quickly after the storm.

    A spokeswoman said the company is also urging its insured customers to heed evacuation orders, having found in a study earlier this year that more than one in four would ignore those orders until the last possible moment.

    For most private insurers, the biggest impact from Sandy is likely to be wind damage to roofs and cars, as well as business losses from prolonged power outages.

    But the brunt of the storm's financial impact may end up falling on the National Flood Insurance Program, which is responsible for almost all flood coverage in the country.

    A unit of the Federal Emergency Management Agency, the NFIP paid out $1.28 billion in losses last year from Irene, making it the fourth-costliest flood event of the last generation.

    More business news:

    Follow NBCNews.com business on Twitter and Facebook

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    Source: http://bottomline.nbcnews.com/_news/2012/10/28/14759550-insurers-prepare-for-impact-of-hurricane-sandy?lite

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    AD: - Relationships, Dating, & Marriage - View

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    New York City Goes Quiet As Storm Nears

    Steve Inskeep speaks with NPR's Zoe Chace, Robert Smith and Jon Hamilton about the impact of Hurricane Sandy on New York City. Schools, the subway, even the floor of the New York Stock Exchange have been shuttered in advance of the storm. Nearly 400,000 New Yorkers in low-lying coastal areas have been told to evacuate.

    Copyright ? 2012 National Public Radio. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.

    STEVE INSKEEP, HOST:

    It's MORNING EDITION from NPR News. I'm Steve Inskeep. Good morning.

    All this morning we've been hearing from reporters up and down the East Coast, in the path of Hurricane Sandy. And next we're going to check up on New York City where forecasters have spoken of a storm surge of six to eleven feet above normal waters. Sandy is still hundreds of miles away from New York, but already the city is experiencing the effects, as we're going to learn. We're going to NPR's Robert Smith who is in New York. And Robert, where are you exactly - what are you seeing?

    ROBERT SMITH, BYLINE: I'm in the far Rockaway, which is a neighborhood of New York City, but is right up against the Atlantic Ocean. And I have to say, the Atlantic Ocean is a lot closer to New York City than it was 12 hours ago because the storm surge has come in, there is - it's high tide and the waves are as high as 12 feet and in some sections the waves are coming up, hitting the boardwalk, sending up sprays of water and actually flooding the streets here in New York City. There are a lot of impassable intersections, now, in far Rockaway. NPR's Zoe Chace is in New York City in Manhattan. Good morning, Zoe.

    INSKEEP: That's pretty amazing because you are hundreds of miles away from the eye of the storm. I wonder if this even technically counts as the storm surge, and yet it's obviously an ominous, early sign.

    SMITH: Yeah, I mean, there is a good part of this, which is the next high tide will be much, much worse. And so people who - they were supposed to evacuate from the section of New York City, a lot of people stayed. But a lot of people are seeing that if it's this bad in the morning, what's it going to look like tonight when the storm is much closer and there's another high tide. And a lot of people are reconsidering their decision to stay in this neighborhood.

    INSKEEP: OK. And let's put that question to NPR's Jon Hamilton who's in our studios here. And Jon, this is a huge storm, how much worse could it get in New York?

    JON HAMIILTON, BYLINE: I think it could get quite a bit worse. This is, like you say, is an enormous storm, there's a huge field of wind, as they say, and it's pushing water toward the coastline here. So, what you have is water pushed into the bay below New York City; you have it pushed into Long Island Sound, above New York City. And there's no place for that water to go except up. And for comparison, you know, last year Irene did some flooding in Manhattan, and that was a storm surge of four and a half feet, just about.

    INSKEEP: I'm thinking about the wind, kind of, hooking around, going north and turning around to the west. And if you imagine the map of New York City, that suggests that water gets pushed up into New York Harbor from below, and also gets pushed in from the side, through Long Island Sound.

    HAMIILTON: Exactly.

    INSKEEP: And so you have huge, huge situation there. Now Robert Smith, earlier, in a different part of Queens in New York City, you said people - some people had not evacuated and were just beginning to get the idea, as the water rose, it might be a good idea. What about the part of the Rockaways you're in now - people evacuated there?

    SMITH: No, there's still a lot of people here. And, and, and, I'm next to an interesting phenomenon here, which is there's still a part of the beach where you can get to the sand. And I've seen car after car pull up with garbage bags, shovel sand in, and bring it back to their homes because they see that the water is going to hit the door, it's going to hit their basement. And so they're doing some last minute sandbagging and deciding to stick out the storm.

    INSKEEP: OK, well, I guess the sand is available as long as the beach survives, anyway. We've got one other reporter on the line, NPR's Zoe Chace is in Manhattan, which, if you look at a map, would seem to be the most protected, the island of Manhattan there in New York Harbor. Is the water rising there, Zoe?

    ZOE CHACE, BYLINE: Yeah, I mean Downtown, Battery Park area, the water has come up over the sea wall. And it's kind of - you can see in pictures it's kind of flooding up around the benches that are so nice to sit on and look out at the Statue of Liberty. But in the middle of the city where I am, you can't quite tell that there's a huge hurricane coming. Like, there's some rain, but not too much, it's pretty warm. There's actually people at work, right now. I've seen a bunch of people headed to work and security guards standing outside.

    INSKEEP: Jon Hamilton, how might the speed of this storm intensify its effects in a place like New York or any of the other coastal areas we've been hearing from throughout the morning?

    HAMIILTON: Well, if forecasters are right and this storm is going to slow down as it approaches the coast, what that means is that it - in any one place, you're getting a longer period of really bad weather. So if it's going, you know, five miles an hour and it's five hundred miles across, you could imagine, you could be in the rain for a very long time.

    INSKEEP: OK, so let's go back to Robert Smith one last time. Robert, can you leave us with an image? What are you seeing where you are?

    SMITH: Well, I'm seeing a spray - a spray as the waves hit the boardwalk and it looks a little bit like Niagra Falls. The wind is pushing the water over and it's just, sort of, like mist in the air.

    INSKEEP: Very dramatic. OK, that's NPR's Robert Smith in far Rockaway Queens. Thanks very much.

    SMITH: You're welcome.

    INSKEEP: Zoe Chase is in Manhattan. Thanks to you.

    CHACE: Thank you.

    INSKEEP: And NPR's Jon Hamilton in our studios here. Thanks to you as well.

    HAMIILTON: My pleasure.

    Copyright ? 2012 National Public Radio. All rights reserved. No quotes from the materials contained herein may be used in any media without attribution to National Public Radio. This transcript is provided for personal, noncommercial use only, pursuant to our Terms of Use. Any other use requires NPR's prior permission. Visit our permissions page for further information.

    NPR transcripts are created on a rush deadline by a contractor for NPR, and accuracy and availability may vary. This text may not be in its final form and may be updated or revised in the future. Please be aware that the authoritative record of NPR's programming is the audio.

    Source: http://www.npr.org/2012/10/29/163845756/new-york-city-goes-quiet-as-storm-nears?ft=1&f=1007

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    Mechanism found for destruction of key allergy-inducing complexes, researchers say

    ScienceDaily (Oct. 28, 2012) ? Researchers have learned how a synthetic molecule destroys complexes that induce allergic responses -- a discovery that could lead to the development of highly potent, rapidly acting interventions for a host of acute allergic reactions.

    The study, published online Oct. 28 in Nature, was led by scientists at the Stanford University School of Medicine and the University of Bern, Switzerland.

    The new inhibitor disarms IgE antibodies, pivotal players in acute allergies, by detaching the antibody from its partner in crime, a molecule called FcR. (Other mechanisms lead to slower-developing allergic reactions.)

    "It would be an incredible intervention if you could rapidly disconnect IgE antibodies in the midst of an acute allergic response," said Ted Jardetzky, PhD, professor of structural biology and senior investigator for the study. It turns out the inhibitor used by the team does just that.

    A myriad of allergens, ranging from ragweed pollen to bee venom to peanuts, can set off IgE antibodies, resulting in allergic reactions within seconds. The new inhibitor destroys the complex that tethers IgE to the cells responsible for the reaction, called mast cells. Severing this connection would be the holy grail of IgE-targeted allergy treatment.

    The first time a potential allergen enters the body, some people respond by making allergen-specific IgE antibodies. These antibodies stick around long after the initial allergen is cleared from the body. Most of the antibodies get snagged by IgE-specific receptors called FcRs, which are exposed on the surface of mast cells. The mast cells are then primed to react the next time a person encounters the allergen.

    Dissociation of this IgE-FcR interaction is a sought-after goal of allergy treatment for a good reason: IgE-coated mast cells are grenades of histamine, and re-encountering the allergen is equivalent to pulling out the clip. When an allergen makes a return visit, it binds to the pre-loaded IgE on the mast cell surface, triggering the release of inflammatory mediators -- including histamine -- that promote the allergic response. As allergy sufferers are well aware, these nasty reactions can occur within a matter of seconds. In a severe allergic response, sudden anaphylactic shock and death can be the result.

    The key to actively disabling the allergic response lies in the separation of IgE from the FcRs on the surface of mast cells. But separating these dangerous couples is a tall order because their interaction is extremely stable -- sensitizing the mast cells for weeks. Currently available treatment using omalizumab (an anti-IgE antibody sold under the trade name Xolair) can block new interactions between IgE and FcR, but it is not designed to pry the molecules apart once they've formed a bond on the surface of a mast cell. So Xolair can dampen the allergic response, but as stated on the product's website: "Xolair is not a rescue medicine and should not be used to treat sudden asthma attacks."

    While simply blocking IgE binding is helpful for some allergy sufferers, when it comes to the rapid quenching of an acute allergic response, "what you'd really like to do is get rid of it," said Jardetzky. Along with scientists at the University of Bern, his team discovered that an engineered protein inhibitor called DARPin E2-79 stripped IgE from the mast cell receptor. Using this inhibitor, "an interaction that normally lasts for hours or days in terms of its stability is stripped off in a matter of seconds," said Jardetzky.

    DARPin E2-79 is one of a family of engineered inhibitors containing protein-binding regions called ankryin repeats. While Jardetzky's group was using structural biology and biophysical approaches to probe the weak spots in the IgE-FcR interaction, scientists at the University of Bern were tinkering with DARPins that dampened IgE's disastrous effects. The collaboration of the two groups resulted in the characterization of DARPin E2-79, an inhibitor that goes beyond mere blockade to actively disassemble the IgE-FcR power couple.

    Jardetzky's group solved E2-79'S structure and used this information to model its interaction with the IgE-FcR pair. Then, using sensitive biochemical techniques that detect step-by-step binding interactions between molecules, the teams were able to tease out the mechanism that the inhibitor uses to break the IgE-FcR bond.

    The researchers found that E2-79 hastens the separation of the two molecules by taking advantage of a moment of weakness in the relationship between IgE and FcR. IgE maintains its interaction with FcR using two contact points, and occasionally one of these points releases while the other one keeps the pair together. Normally this brief looseness isn't enough to separate the couple, but E2-79 can swoop into the small space between them, effectively driving the couple apart.

    While E2-79 is the first molecule to display these IgE stripping characteristics, Jardetzky hopes that this work will stimulate the discovery of smaller compounds capable of working even more efficiently. Drug developers generally expect large macromolecules like E2-79 to be less potent than small molecule inhibitors and unlikely to be able to disrupt complexes, so the fact that E2-79 worked so well was a surprise. Small molecules are more amenable to oral administration, and are easier and cheaper to manufacture than large macromolecules. "Now we're in the hunt for a small molecule that could have this kind of activity. That would be the real hit," said Jardetzky.

    The discovery of E2-79's mechanism of IgE inhibition could lead to rapid discoveries from other labs as well. Now that scientists know what mechanism to look for, they may be inspired to dig back through freezers full of IgE inhibitors that were identified years ago, said Jardetzky. In the light of techniques described in this study, perhaps once-neglected inhibitors will show new promise in the treatment of allergic disease.

    The study's primary authorship was shared between Beomkyu Kim, PhD, a Stanford graduate student, and Alexander Eggel, PhD, at the University of Bern. The other Stanford co-author is research assistant Svetlana Tarchevskaya.

    The study was funded by the National Institutes of Health, the American Asthma Foundation and the Swiss National Science Foundation.

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    Story Source:

    The above story is reprinted from materials provided by Stanford University Medical Center. The original article was written by Jessica Shugart.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Beomkyu Kim, Alexander Eggel, Svetlana S. Tarchevskaya, Monique Vogel, Heino Prinz, Theodore S. Jardetzky. Accelerated disassembly of IgE?receptor complexes by a disruptive macromolecular inhibitor. Nature, 2012; DOI: 10.1038/nature11546

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/SyVXKhtXvlw/121028142316.htm

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